Antibiotics are dangerous for the brain
A team of experts representing the max delbrück center for molecular medicine in Germany made a statement that antibiotic use for a long time can lead to memory problems and deterioration of a number of other functions of the human brain. According to the researchers, the reason for this immune cells involved in the transfer of information between the brain and intestines.
A study conducted by biologists showed that a long course of antibiotics provokes a decrease in the rate of birth of new brain cells. First of all, this was manifested in the hippocampus — part of the limbic system of the brain involved, including the transition of short-term memory in the long-term, as well as in the formation of emotions.
In order to come to such conclusions, experts conducted an experiment on laboratory mice, some of which were added to the water antibiotics, while others were a control group.
As expected, antibiotics have made the intestinal microflora of mice poorer. However, experts have noticed another important detail: a decrease in the number of microorganisms in the intestine was accompanied by the fact that the mice became smaller and certain immune cells — located in the brain monocytes Ly6C(hi). As shown by additional experiments, the rate of neurogenesis directly depended on their number.
Later, scientists were able to restore the immune cells and normal brain function, after one of them in the intestine were introduced certain strains of bacteria, and others were given the opportunity to run in the wheel to restore health. At the same time, it did not help mice who simply “transplanted” rodent bacteria from the control group.
The researchers emphasize that on the basis of their work should not be too far — reaching conclusions-the experiment was conducted on mice and it used a “cocktail” of powerful antibiotics, so to argue that the course of any antibiotics has a significant impact on the human brain, at this stage of the study would be a significant exaggeration.
However, experts suggest that their findings will provide a better understanding of the effects of antibiotics, as well as likely to help better treat some people with mental health problems such as schizophrenia or clinical depression.
His research scientists published in the journal Cell Reports.